Sci Rep. 2018 Jan 11;8(1):538. doi: 10.1038/s41598-017-18993-5.
Rémy Vandaele, Jessica Aceto, Marc Muller, Frédérique Péronnet, Vincent Debat, Ching-Wei Wang, Cheng-Ta Huang, Sébastien Jodogne, Philippe Martinive, Pierre Geurts, Raphaël Marée
The detection of anatomical landmarks in bioimages is a necessary but tedious step for geometric morphometrics studies in many research domains. We propose variants of a multi-resolution tree-based approach to speed-up the detection of landmarks in bioimages. We extensively evaluate our method variants on three different datasets (cephalometric, zebrafish, and drosophila images). We identify the key method parameters (notably the multi-resolution) and report results with respect to human ground truths and existing methods. Our method achieves recognition performances competitive with current existing approaches while being generic and fast. The algorithms are integrated in the open-source Cytomine software and we provide parameter configuration guidelines so that they can be easily exploited by end-users. Finally, datasets are readily available through a Cytomine server to foster future research.
